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Biological Laboratory Regulation

Proposed Amendments to Biological Laboratory and Recombinant DNA Regulations

The Boston Public Health Commission (BPHC) and Boston Board of Health are accepting written comments on proposed amendments to Boston’s Biological Laboratory Regulation and Recombinant DNA Use and Technology Regulation. BPHC proposes to promulgate these amendments pursuant to M.G.L. c. 111, § 31; M.G.L. c. 111, App. §§ 2-1, 2-3, 2-6(b), 2-6(j), 2-7(a)(1), and 2-7(a)(15).

The proposed amendments would:
  • Rescind the Recombinant DNA Use and Technology Regulation,
  • Incorporate the regulation of the use of recombinant DNA (rDNA) into the Biological Lab Regulation,
  • Formalize a requirement that each individual BSL-4 research project undergo review by the Boston Biosafety Committee prior to receiving approval by BPHC, and
  • Revise definitions and citations to align with updated national guidance documents.

A copy of the proposed amendments is available here.

An issue brief can be found here.

A presentation to the Board of Health can be found here.

A public hearing is scheduled for January 7th, 2019 from 5:00pm to 7:00pm at the Boston Public Health Commission, 1010 Massachusetts Avenue, Hayes Conference Room, 2nd Floor, Boston, MA 02118.

Written comments may be submitted through January 10th by email to  or by mail to the Boston Public Health Commission, ATTN: Board of Health, 1010 Massachusetts Avenue, 6th Floor, Boston, MA 02118.   

Please feel free to reach out to the Board Office at 617-534-5855 with any questions.  

Additional Documents

Biological Laboratory Regulation - promulgated on September 19, 2006

Biological Laboratory Regulation Guidelines​

Boston Public Health Commission
1010 Massachusetts Ave, 6th Floor, Boston, MA 02118.
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